Summary

NeoGen nitrogen plasma is an exciting technology used “off-label” by clinicians for a variety of skin issues, notably in the treatment of acne and for enhancement of penetration of actives. This mini-review aims to give some theoretical background to these uses, suggests mechanisms for the activity seen in clinics, and gives suggestions for future testing to scientifically validate the claims made by clinicians. The review shows that given plasma’s unique mix of rapid heating, mild UV, visible light and reactive species, it is unsurprising that anti-microbial activity, anti-acne efficacy and drug penetration enhancement is seen.

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